Synthesis of Some Novel Quinazoline Derivatives Having Anti-Cancer Activity

Cancer is the uncontrolled growth and spread of cells. It can affect any part of the body. The growths often invade surrounding tissue and can metastasize to distant sites [1]. Majority of the cancer (90%-95%) are caused by frequent use of tobacco, obesity or over weight, chronic infections and prolonged exposure to radiations and a notable percentage (5%-10%) are due to heredity. Most cancer can be treated by radiology, chemo-therapy and surgery [2]. According to WHO, in 2012 approximately 14 million new cases and 8.2 million cancer related deaths worldwide. The number of new cases is projected to upsurge by about 70% over the next 2 decades. Among men, the most common sites of cancer diagnosed in 2012 were lung, prostate, colorectum, stomach and liver cancer; among women the most common sites diagnosed were breast, colorectum, lung, cervix and stomach cancer.